Jun 04 2021
Gallo E, Kelil A, Haughey M, Cazares-Olivera M, Yates BP, Zhang M, Wang NY, Blazer L, Carderelli L, Adams JJ, Kossiakoff AA, Wells JA, Xie W, Sidhu SS
J Mol Biol. 2021 Jun 4;433(15):167090. doi: 10.1016/j.jmb.2021.167090.
PMID: 34090922
Members of the αv family of integrins regulate activation of …
May 21 2021
Garland E, Rugema N, Sieng M, Muralidharan K, Fisher I, Everly A, Erramilli S, Van Camp M, Emmerson L, Reyes J, Kossiakoff AA, Lyon, A
The FASEB Journal, 35. 2021 May 14. https://doi.org/10.1096/fasebj.2021.35.S1.03032
Phospholipase C (PLC) ε enzymes hydrolyze phosphatidylinositol lipids at cellular membranes to produce inositol phosphates (IPx) and …
Mar 25 2021
Slezak T, Kossiakoff AA
J Mol Biol. 2021 Mar 25;doi: 10.1016/j.jmb.2021.166956.
PMID: 33775667
Abstract
The Covid-19 pandemic is a centenarial global catastrophe. Similar events are likely to be recurring with more frequency in the future. The inability to control the virus’ impact is caused by many …
Sep 01 2020
Lokareddy RK, Ko YH, Hong N, Doll SG, Paduch M, Niederweis M, Kossiakoff AA, Cingolani G
Acta Crystallogr D Struct Biol. 2020 Sep 1;76(Pt 9):876-888.
PMID: 32876063
Abstract
The genome-packaging motor of tailed bacteriophages and herpesviruses is a multisubunit protein complex formed by several copies of …
Aug 07 2020
Tsutsumi N, Mukherjee S, Waghray D, Janda CY, Jude KM, Miao Y, Burg JS, Aduri NG, Kossiakoff AA, Gati C, Garcia KC.
Elife. 2020 Aug 7;9:e58464.
PMID: 32762848
Abstract
Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell biology, yet …
Mar 29 2020
Mukherjee S, Erramilli SK, Ammirati M, Alvarez FJD, Fennell KF, Purdy MD, Skrobek BM, Radziwon K, Coukos J, Kang Y, Dutka P, Gao X, Qiu X, Yeager M, Eric Xu H, Han S, Kossiakoff AA
Nat Commun 2020 Mar;11(1):1598
PMID: 32221310
Abstract
We propose the concept of universal fiducials based on a set of pre-made …
Feb 26 2020
Bloch JS, Pesciullesi G, Boilevin J, Nosol K, Irobalieva RN, Darbre T, Aebi M, Kossiakoff AA, Reymond JL, Locher KP
Nature 2020 03;579(7799):443-447
PMID: 32103179
Abstract
In eukaryotic protein N-glycosylation, a series of glycosyltransferases catalyse the biosynthesis of a dolichylpyrophosphate-linked oligosaccharide before its transfer onto acceptor proteins. The final seven steps occur in the lumen …
Dec 02 2019
Kim J, Tan YZ, Wicht KJ, Erramilli SK, Dhingra SK, Okombo J, Vendome J, Hagenah LM, Giacometti SI, Warren AL, Nosol K, Roepe PD, Potter CS, Carragher B, Kossiakoff AA, Quick M, Fidock DA, Mancia F
Nature 2019 Nov;
PMID: 31776516
Abstract
The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts to control …
Nov 30 2019
Dutka P, Mukherjee S, Gao X, Kang Y, de Waal PW, Wang L, Zhuang Y, Melcher K, Zhang C, Xu HE, Kossiakoff AA
Structure 2019 Oct;
PMID: 31669042
Abstract
“Universal” synthetic antibody (sAB)-based fiducial marks have been generated by customized phage display selections to facilitate the rapid structure determination of G protein-coupled receptor (GPCR) signaling …
Oct 18 2019
Slezak T, Bailey LJ, Jaskolowski M, Nahotko DA, Filippova EV, Davydova EK, Kossiakoff AA
Protein Sci. 2019 Oct;
PMID: 31622515
Abstract
Engineered recombinant antibody-based reagents are rapidly supplanting traditionally derived antibodies in many cell biological applications. A particularly powerful aspect of these engineered reagents is that other modules having myriad functions can be attached to …