Jul 05 2022
Peiqiang Feng, Xudong Wu, Satchal K Erramilli, Joao A Paulo, Pawel Knejski, Steven P Gygi, Anthony A Kossiakoff, Tom A Rapoport
Nature. 2022 Jun 29
PMID: 35768507 DOI: 10.1038/s41586-022-04903-x
Peroxisomes are ubiquitous organelles that house various metabolic reactions and are essential for human health1-4. Luminal peroxisomal proteins are imported from …
Jul 05 2022
Hongtao Liu, Rossitza N. Irobalieva, Rose Bang-Sørensen, Kamil Nosol, Somnath Mukherjee, Parth Agrawal, Bruno Stieger, Anthony A. Kossiakoff & Kaspar P. Locher
Cell Research (2022) 0:1–4
PMID: 35726088 DOI: 10.1038/s41422-022-00680-4
The sodium taurocholate (TC) co-transporting polypeptide NTCP (SLC10A1) is a secondary active membrane transport protein that mediates the uptake of …
Jul 05 2022
Christopher J Bley, Si Nie, George W Mobbs, Stefan Petrovic, Anna T Gres, Xiaoyu Liu, Somnath Mukherjee, Sho Harvey, Ferdinand M Huber, Daniel H Lin, Bonnie Brown, Aaron W Tang, Emily J Rundlet, Ana R Correia, Shane Chen, Saroj G Regmi, Taylor A Stevens, Claudia A Jette, Mary Dasso, Alina Patke, Alexander F Palazzo, …
Jul 05 2022
Cristina Arrigoni, Marco Lolicato, David Shaya, Ahmed Rohaim, Felix Findeisen, Lam-Kiu Fong, Claire M Colleran, Pawel Dominik, Sangwoo S Kim, Jonathan P Schuermann, William F DeGrado, Michael Grabe, Anthony A Kossiakoff, Daniel L Minor
Nat Struct Mol Biol. 2022 Jun;29(6):537-548.
PMID: 35655098 DOI: 10.1038/s41594-022-00775-x
Every voltage-gated ion channel (VGIC) …
May 13 2022
Marcin Ura, Somnath Mukherjee, Edyta Marcon, Stefan A Koestler, Anthony A Kossiakoff
J Mol Biol. 2022 Apr 22;167602.
PMID: 35469831 DOI: 10.1016/j.jmb.2022.167602
High-performance affinity reagents are essential tools to enable biologists to profile the cellular location and composition of macromolecular complexes undergoing dynamic reorganization. To support further development …
Apr 07 2022
Khuram U. Ashraf, Rie Nygaard, Owen N. Vickery, Satchal K. Erramilli, Carmen M. Herrera, Thomas H. McConville, Vasileios I. Petrou, Sabrina I. Giacometti, Meagan Belcher Dufrisne, Kamil Nosol, Allen P. Zinkle, Chris L. B. Graham, Michael Loukeris, Brian Kloss, Karolina Skorupinska-Tudek, Ewa Swiezewska, David I. Roper, Oliver B. Clarke, Anne-Catrin Uhlemann, Anthony A. Kossiakoff, …
Mar 07 2022
Shion A Lim, Jie Zhou, Alexander J Martinko, Yung-Hua Wang, Ekaterina V Filippova, Veronica Steri, Donghui Wang, Soumya G Remesh, Jia Liu, Byron Hann, Anthony A Kossiakoff, Michael J Evans, Kevin K Leung, James A Wells
J Clin Invest. 2022 Feb 15;132(4):e154604.
PMID: 35166238 PMCID: PMC8843743 DOI: 10.1172/JCI154604
Extracellular proteolysis is …
Mar 04 2022
Ahmed Rohaim, Tomasz Slezak, Young Hoon Koh, Lydia Blachowicz, Anthony A Kossiakoff, Benoît Roux
J Gen Physiol. 2022 Apr 4;154(4):e202112965.
PMID: 35234830 DOI: 10.1085/jgp.202112965
Engineered antibody fragments (Fabs) have made major impacts on structural biology research, particularly to aid structural determination of membrane proteins. Nonetheless, Fabs generated by traditional …
Dec 06 2021
Joël S Bloch, Somnath Mukherjee, Julia Kowal, Ekaterina V Filippova, Martina Niederer, Els Pardon, Jan Steyaert, Anthony A Kossiakoff, Kaspar P Locher
Proc Natl Acad Sci U S A. 2021 Nov 23;118(47)
PMID: 34782475 DOI: 10.1073/pnas.2115435118
With conformation-specific nanobodies being used for a wide range of structural, biochemical, …
Oct 24 2021
Kamil Nosol, Rose Bang-Sørensen, Rossitza N Irobalieva, Satchal K Erramilli, Bruno Stieger, Anthony A Kossiakoff, Kaspar P Locher
Proc Natl Acad Sci USA 2021 Aug 17;118(33):e2106702118.
PMID: 34385322 PMCID: PMC8379956 (available on 2022-02-12)
DOI: 10.1073/pnas.2106702118
ABCB4 is expressed in hepatocytes and translocates phosphatidylcholine into bile canaliculi. …